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1

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

Athukoralage, Januka S., McMahon, Stephen A., Zhang, Changyi, Grüschow, Sabine, Graham, Shirley, Krupovic, Mart, Whitaker, Rachel J., Gloster, Tracey M., White, Malcolm F.

Journal:

Year:

2020

Language:

english

File:

PDF, 20.67 MB

english, 2020

2

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

McMahon, Stephen A., Zhu, Wenlong, Graham, Shirley, Rambo, Robert, White, Malcolm F., Gloster, Tracey M.

Journal:

Nature Communications

Year:

2020

Language:

english

File:

PDF, 2.11 MB

english, 2020

3

Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues

Matilde Aguilar, Tracey M. Gloster, M. Isabel García-Moreno, Carmen Ortiz Mellet, Gideon J. Davies, Amadeu Llebaria, Josefina Casas, Meritxell Egido-Gabás, José M. García Fernandez

Journal:

Year:

2008

Language:

english

File:

PDF, 443 KB

english, 2008

4

Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors

Robert P. Gibson, Tracey M. Gloster, Shirley Roberts, R. Anthony J. Warren, Isabel Storch de Gracia, Ángela García, Jose L. Chiara, Gideon J. Davies

Journal:

Angewandte Chemie

Year:

2007

Language:

english

File:

PDF, 313 KB

english, 2007

5

Molecular Basis for Trehalase Inhibition Revealed by the Structure of Trehalase in Complex with Potent Inhibitors

Robert P. Gibson, Tracey M. Gloster, Shirley Roberts, R. Anthony J. Warren, Isabel Storch de Gracia, Ángela García, Jose L. Chiara, Gideon J. Davies

Journal:

Angewandte Chemie International Edition

Year:

2007

Language:

english

File:

PDF, 314 KB

english, 2007

6

Common Inhibition of Both β-Glucosidases and β-Mannosidases by Isofagomine Lactam Reflects Different Conformational Itineraries for Pyranoside Hydrolysis

Florence Vincent, Tracey M. Gloster, James Macdonald, Carl Morland, Robert V. Stick, Fernando M. V. Dias, José A. M. Prates, Carlos M. G. A. Fontes, Harry J. Gilbert, Gideon J. Davies

Journal:

Year:

2004

Language:

english

File:

PDF, 195 KB

english, 2004

7

Dissection of Conformationally Restricted Inhibitors Binding to a β-Glucosidase

Tracey M. Gloster, Robert Madsen, Gideon J. Davies

Journal:

Year:

2006

Language:

english

File:

PDF, 383 KB

english, 2006

8

Total Syntheses of Casuarine and Its 6-O-α-Glucoside: Complementary Inhibition towards Glycoside Hydrolases of the GH31 and GH37 Families

Francesca Cardona, Camilla Parmeggiani, Enrico Faggi, Claudia Bonaccini, Paola Gratteri, Lyann Sim, Tracey M. Gloster, Shirley Roberts, Gideon J. Davies, David R. Rose, Andrea Goti

Journal:

Chemistry - A European Journal

Year:

2009

Language:

english

File:

PDF, 892 KB

english, 2009

9

ChemInform Abstract: Glycosidase Inhibition: Assessing Mimicry of the Transition State

Tracey M. Gloster, Gideon J. Davies

Journal:

Year:

2010

File:

PDF, 15 KB

2010

10

ChemInform Abstract: Casuarine-6-O-α-D-glucoside and Its Analogues Are Tight Binding Inhibitors of Insect and Bacterial Trehalases.

Francesca Cardona, Andrea Goti, Camilla Parmeggiani, Paolo Parenti, Matilde Forcella, Paola Fusi, Laura Cipolla, Shirley M. Roberts, Gideon J. Davies, Tracey M. Gloster

Journal:

Year:

2010

File:

PDF, 20 KB

2010

11

6″-Azido-6″-deoxy-UDP-N-acetylglucosamine as a glycosyltransferase substrate

Alain Mayer, Tracey M. Gloster, Wayne K. Chou, David J. Vocadlo, Martin E. Tanner

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 322 KB

english, 2011

12

Divergence of Catalytic Mechanism within a Glycosidase Family Provides Insight into Evolution of Carbohydrate Metabolism by Human Gut Flora

Tracey M. Gloster, Johan P. Turkenburg, Jennifer R. Potts, Bernard Henrissat, Gideon J. Davies

Journal:

Chemistry & Biology

Year:

2008

Language:

english

File:

PDF, 475 KB

english, 2008

13

Elevation of Global O-GlcNAc in Rodents Using a Selective O-GlcNAcase Inhibitor Does Not Cause Insulin Resistance or Perturb Glucohomeostasis

Matthew S. Macauley, Xiaoyang Shan, Scott A. Yuzwa, Tracey M. Gloster, David J. Vocadlo

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 951 KB

english, 2010

14

Inhibition of O-GlcNAcase Using a Potent and Cell-Permeable Inhibitor Does Not Induce Insulin Resistance in 3T3-L1 Adipocytes

Matthew S. Macauley, Yuan He, Tracey M. Gloster, Keith A. Stubbs, Gideon J. Davies, David J. Vocadlo

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

15

Structure of a carbohydrate esterase from Bacillus anthracis

Leoni Oberbarnscheidt, Edward J. Taylor, Gideon J. Davies, Tracey M. Gloster

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 255 KB

english, 2007

16

Inhibition of a bacterialO-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

Yuan He, Abigail K. Bubb, Keith A. Stubbs, Tracey M. Gloster, Gideon J. Davies

Journal:

Year:

2011

Language:

english

File:

PDF, 476 KB

english, 2011

17

Structural insight into the mechanism of streptozotocin inhibition of O-GlcNAcase

Yuan He, Carlos Martinez-Fleites, Abigail Bubb, Tracey M. Gloster, Gideon J. Davies

Journal:

Carbohydrate Research

Year:

2009

Language:

english

File:

PDF, 977 KB

english, 2009

18

Hijacking a biosynthetic pathway yields a glycosyltransferase inhibitor within cells

Gloster, Tracey M, Zandberg, Wesley F, Heinonen, Julia E, Shen, David L, Deng, Lehua, Vocadlo, David J

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 958 KB

english, 2011

19

Recent structural insights into the expanding world of carbohydrate-active enzymes

Gideon J Davies, Tracey M Gloster, Bernard Henrissat

Journal:

Current Opinion in Structural Biology

Year:

2005

Language:

english

File:

PDF, 579 KB

english, 2005

20

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

Gloster, Tracey M, Vocadlo, David J

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 974 KB

english, 2012

21

Insights into the Structural Determinants of Cohesin—Dockerin Specificity Revealed by the Crystal Structure of the Type II Cohesin from Clostridium thermocellum SdbA

Ana L. Carvalho, Virginia M.R. Pires, Tracey M. Gloster, Johan P. Turkenburg, José A.M. Prates, Luís M.A. Ferreira, Maria J. Romão, Gideon J. Davies, Carlos M.G.A. Fontes, Harry J. Gilbert

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 1.06 MB

english, 2005

22

Structural snapshots of the reaction coordinate for O-GlcNAc transferase

Lazarus, Michael B, Jiang, Jiaoyang, Gloster, Tracey M, Zandberg, Wesley F, Whitworth, Garrett E, Vocadlo, David J, Walker, Suzanne

Journal:

Nature Chemical Biology

Year:

2012

Language:

english

File:

PDF, 732 KB

english, 2012

23

Glycosidase inhibition by ring-modified castanospermine analogues: tackling enzyme selectivity by inhibitor tailoring

Aguilar-Moncayo, Matilde, Gloster, Tracey M., Turkenburg, Johan P., García-Moreno, M. Isabel, Ortiz Mellet, Carmen, Davies, Gideon J., García Fernández, José M.

Journal:

Organic & Biomolecular Chemistry

Year:

2009

Language:

english

File:

PDF, 344 KB

english, 2009

24

Iminosugar Glycosidase Inhibitors: Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases

Zechel, David L., Boraston, Alisdair B., Gloster, Tracey, Boraston, Catherine M., Macdonald, James M., Tilbrook, D. Matthew G., Stick, Robert V., Davies, Gideon J.

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 478 KB

english, 2003

25

Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease

He, Xu, Haselhorst, Thomas, von Itzstein, Mark, Kolarich, Daniel, Packer, Nicolle H., Gloster, Tracey M., Vocadlo, David J., Clarke, Lorne A., Qian, Yi, Kermode, Allison R.

Journal:

Nature Communications

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

26

Signature Active Site Architectures Illuminate the Molecular Basis for Ligand Specificity in Family 35 Carbohydrate Binding Module,

Correia, Márcia A. S., Abbott, D. Wade, Gloster, Tracey M., Fernandes, Vânia O., Prates, José A. M., Montanier, Cedric, Dumon, Claire, Williamson, Michael P., Tunnicliffe, Richard B., Liu, Ziyuan,

Journal:

Year:

2010

Language:

english

File:

PDF, 4.49 MB

english, 2010

27

Development of inhibitors as research tools for carbohydrate-processing enzymes

Gloster, Tracey M.

Journal:

Biochemical Society Transactions

Year:

2012

Language:

english

File:

PDF, 1009 KB

english, 2012

28

Glycosidase Inhibition: An Assessment of the Binding of 18 Putative Transition-State Mimics

Gloster, Tracey M., Meloncelli, Peter, Stick, Robert V., Zechel, David, Vasella, Andrea, Davies, Gideon J.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 608 KB

english, 2007

29

Structural Studies of the β-Glycosidase from Sulfolobus solfataricus in Complex with Covalently and Noncovalently Bound Inhibitors †

Gloster, Tracey M., Roberts, Shirley, Ducros, Valérie M-A., Perugino, Giuseppe, Rossi, Mosè, Hoos, Roland, Moracci, Marco, Vasella, Andrea, Davies, Gideon J.

Journal:

Year:

2004

Language:

english

File:

PDF, 540 KB

english, 2004

30

Structural, Kinetic, and Thermodynamic Analysis of Glucoimidazole-Derived Glycosidase Inhibitors †,‡

Gloster, Tracey M., Roberts, Shirley, Perugino, Giuseppe, Rossi, Mosè, Moracci, Marco, Panday, Narendra, Terinek, Miroslav, Vasella, Andrea, Davies, Gideon J.

Journal:

Year:

2006

Language:

english

File:

PDF, 394 KB

english, 2006

31

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10AElectronic supplementary information (ESI) available: kinetics and structural methods. See http://www.rsc.org/suppdata/cc/b4/b405152a/

Gloster, Tracey M., Williams, Spencer J., Roberts, Shirley, Tarling, Chris A., Wicki, Jacqueline, Withers, Stephen G., Davies, Gideon J.

Journal:

Chemical Communications

Year:

2004

Language:

english

File:

PDF, 183 KB

english, 2004

32

A xylobiose-derived isofagomine lactam glycosidase inhibitor binds as its amide tautomerElectronic supplementary information (ESI) available: details of data and structure quality for complex of 1 with Xyn10A. See http://www.rsc.org/suppdata/cc/b3/b301829f/

Gloster, Tracey, Williams, Spencer J., Tarling, Chris A., Roberts, Shirley, Dupont, Claude, Jodoin, Pascale, Shareck, François, Withers, Stephen G., Davies, Gideon J.

Journal:

Chemical Communications

Year:

2003

Language:

english

File:

PDF, 213 KB

english, 2003

33

Casuarine-6-O-α-d-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Cardona, Francesca, Goti, Andrea, Parmeggiani, Camilla, Parenti, Paolo, Forcella, Matilde, Fusi, Paola, Cipolla, Laura, Roberts, Shirley M., Davies, Gideon J., Gloster, Tracey M.

Journal:

Chemical Communications

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

34

Characterization and downstream mannose phosphorylation of human recombinant α-L-iduronidase produced in Arabidopsis complex glycan-deficient ( cgl ) seeds

He, Xu, Pierce, Owen, Haselhorst, Thomas, von Itzstein, Mark, Kolarich, Daniel, Packer, Nicolle H., Gloster, Tracey M., Vocadlo, David J., Qian, Yi, Brooks, Doug, Kermode, Allison R.

Journal:

Plant Biotechnology Journal

Year:

2013

Language:

english

File:

PDF, 348 KB

english, 2013

35

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

Stubbs, Keith A., Bacik, John-Paul, Perley-Robertson, G. Evan, Whitworth, Garrett E., Gloster, Tracey M., Vocadlo, David J., Mark, Brian L.

Journal:

Year:

2013

Language:

english

File:

PDF, 563 KB

english, 2013

36

Advances in understanding glycosyltransferases from a structural perspective

Gloster, Tracey M

Journal:

Current Opinion in Structural Biology

Year:

2014

Language:

english

File:

PDF, 2.49 MB

english, 2014

37

D-Glucosylated Derivatives of Isofagomine and Noeuromycin and Their Potential as Inhibitors of β-Glycoside Hydrolases

Meloncelli, Peter J., Gloster, Tracey M., Money, Victoria A., Tarling, Chris A., Davies, Gideon J., Withers, Stephen G., Stick, Robert V.

Journal:

Australian Journal of Chemistry

Year:

2007

Language:

english

File:

PDF, 723 KB

english, 2007

38

Mechanism of Human Nucleocytoplasmic Hexosaminidase D

Alteen, Matthew G., Oehler, Verena, Nemčovičová, Ivana, Wilson, Iain B. H., Vocadlo, David J., Gloster, Tracey M.

Journal:

Year:

2016

Language:

english

File:

PDF, 1016 KB

english, 2016

39

Mechanism, Structure, and Inhibition of O-GlcNAc Processing Enzymes

Gloster, Tracey, Vocadlo, David

Journal:

Current Signal Transduction Therapy

Year:

2010

Language:

english

File:

PDF, 833 KB

english, 2010

40

Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars

Adamson, Christopher, Pengelly, Robert J., Shamsi Kazem Abadi, Saeideh, Chakladar, Saswati, Draper, Jason, Britton, Robert, Gloster, Tracey M., Bennet, Andrew J.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 2.49 MB

english, 2016

41

Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars

Adamson, Christopher, Pengelly, Robert J., Shamsi Kazem Abadi, Saeideh, Chakladar, Saswati, Draper, Jason, Britton, Robert, Gloster, Tracey M., Bennet, Andrew J.

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 2.42 MB

english, 2016

42

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing

Liu, Tai-Wei, Zandberg, Wesley F., Gloster, Tracey M., Deng, Lehua, Murray, Kelsey D., Shan, Xiaoyang, Vocadlo, David J.

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

43

Metabolic Inhibitors of O-GlcNAc Transferase That Act In Vivo Implicate Decreased O-GlcNAc Levels in Leptin-Mediated Nutrient Sensing

Liu, Tai-Wei, Zandberg, Wesley F., Gloster, Tracey M., Deng, Lehua, Murray, Kelsey D., Shan, Xiaoyang, Vocadlo, David J.

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 1.45 MB

english, 2018

44

New irreversible α-L-iduronidase inhibitors and activity-based probes

Artola, Marta, Kuo, Chi-Lin, McMahon, Stephen A., Oehler, Verena, Hansen, Thomas, van der Lienden, Martijn, He, Xu, van den Elst, Hans, Florea, Bogdan I., Kermode, Allison R., Gloster, Tracey M., van

Journal:

Chemistry - A European Journal

Year:

2018

Language:

english

File:

PDF, 1.99 MB

english, 2018

45

Linear Eyring Plots Conceal a Change in the Rate-Limiting Step in an Enzyme Reaction

Machado, Teresa F. G., Gloster, Tracey M., da Silva, Rafael G.

Journal:

Year:

2018

Language:

english

File:

PDF, 1.95 MB

english, 2018

46

Exploitation of carbohydrate processing enzymes in biocatalysis

Gloster, Tracey M.

Journal:

Current Opinion in Chemical Biology

Year:

2020

File:

PDF, 1023 KB

2020

47

Analysis of the product streams obtained on butanosolv pretreatment of draff

Foltanyi, Flora, Hawkins, Julie E., Panovic, Isabella, Bird, Eve J., Gloster, Tracey M., Lancefield, Christopher S., Westwood, Nicholas J.

Journal:

Biomass and Bioenergy

Year:

2020

File:

PDF, 288 KB

2020

48

Dissecting the Mechanism of ( R )-3-Hydroxybutyrate Dehydrogenase by Kinetic Isotope Effects, Protein Crystallography, and Computational Chemistry

Machado, Teresa F. G., Purg, Miha, McMahon, Stephen A., Read, Benjamin J., Oehler, Verena, Ãqvist, Johan, Gloster, Tracey M., da Silva, Rafael G.

Journal:

Year:

2020

File:

PDF, 5.38 MB

2020